학   력

2000.03. ~ 2007.02. 강릉원주대학교 생물학과 학사

2007.03. ~ 2009.02. 강릉원주대학교 생물학과 석사

2010.07. ~ 2014.12. 미국 테네시 녹스빌 주립 대학교 박사

주요경력

2015.07. ~ 2018.08. 미국 사우스 캘롤나이나 의과대학 생화학분자생물학과 박사후연구원

2018.08. ~ 현재. 강릉원주대학교 생물학과 부교수

관심연구분야

암 특이적 대사 및 세포노화를 조절하는 비암호화 RNA 의 분자기전

세포 대사 변화와 연관된 전사 후 유전자 발현 조절 

RNA 메틸화와 노화 및 암 대사의 연관성

천연물에 의한 유전자 발현 조절 기전연구

연구논문 (2020년 이후)

Hyeon-Jeong Jeong, Jun Seok Wang, Kyung-Won Min, Chang-Ho Lee, Hyun Bong Park 

Bioactivity-guided characterisation of iberin from Cakile edentula (Bigelow) Hook. inducing apoptosis in human melanoma cells 

Natural Product Research (2025) Jun 5:1-7

Mun H, Choi KM, Fei Q, Giraldo AEL, Lee JW, Kim K, Min KW, Shi L, Bedford MT, Kim DC, Chun YL, Ryu S, Kim D, Chang JH, Kang SU, Lee W, Yoon JH 

SARS-CoV-2 RNA-binding protein suppresses extracellular miRNA release 

RNA Biology (2025) Jul 1; 22(1):1-17

Yeom E, Mun H, Lim J, Chun YL, Min KW, Lambert J, Cowart LA, Pierce JS, Ogretmen B, Cho JH, Chang JH, Buchan JR, Pitt J, Kaeberlein M, Kang SU, Kwon ES, Ko S, Choi KM, Lee YS, Ha YS, Kim SJ, Lee KP, Kim HS, Yang SY, Shin CH, Yoon JH, Lee KS 

Phosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging. 

Aging Cell (2025) Mar 11:e70022

Kyung-Won Min*, Kyoung-Min Choi*, Hyejin Mun, Seungbeom Ko, Ji Won Lee, Cari A Sagum, Mark T Bedford, Young-Kook Kim, Joe R Delaney, Jung-Hyun Cho, Ted M Dawson, Valina L Dawson, Waleed Twal, Dong-Chan Kim, Clarisse H Panganiban, Hainan Lang, Xin Zhou, Seula Shin, Jian Hu, Tilman Heise, Sang-Ho Kwon, Dongsan Kim, Young Hwa Kim, Sung-Ung Kang, Kyungmin Kim, Sydney Lewis, Ahmet Eroglu, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Junyang Jung, Je-Hyun Yoon 

Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release

Journal of Cell Science (2024) Nov 1; 137(21):jcs261575 (*Co-first authors)

Hyung-Joo Chung, Thy NC Nguyen, Ji Won Lee, Youngbuhm Huh, Seungbeom Ko, Heejin Lim, Hyewon Seo, Young-Geun Ha, Jeong Ho Chang, Jae-Sung Woo, Ji-Joon Song, So-Woon Kim, Jin San Lee, Jung-Soon Mo, Boyoun Park, Kyung-Won Min, Je-Hyun Yoon, Min-Sik Kim, Junyang Jung, Na Young Jeong

Targeting the Hippo pathway in Schwann cells ameliorates peripheral nerve degeneration via a polypharmacological mechanism

Neurotherapeutics (2024) Oct 8; 21(6):e00458

Seong Ho Park, Ji Won Kang, Ga Hyeon Park, So-Jung Jo, Kyung-Won Min, Kyu Song Lee and Hyun Bong Park 

Isolation and Identification of Antifungal Metabolites from Juncus torreyi

Natural Product Sciences (2024) June 1; 30(2):161-166

Kyung-Won Min*, Myung Hyun Jo, Minseok Song, Ji Won Lee, Min Ji Shim, Kyungmin Kim, Hyun Bong Park, Shinwon Ha, Hyejin Mun, Ahsan Polash, Markus Hafner, Jung-Hyun Cho, Dongsan Kim, Ji-Hoon Jeong, Seungbeom Ko, Sungchul Hohng, Sung-Ung Kang* and Je-Hyun Yoon* 

Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing

RNA Biology (2024) Feb 19; 21(1):1-15 (*Co-corresponding authors)

 

Ji Won Lee, Hyejin Mun, Jeong-Hyun Kim, Seungbeom Ko, Young-Kook Kim, Min Ji Shim, Kyungmin Kim, Chul Woong Ho, Hyun Bong Park, Meesun Kim, Chaeyoung Lee, Si Ho Choi, Jung-Woong Kim, Ji-Hoon Jeong, Je-Hyun Yoon, Kyung-Won Min*, Tae Gen Son* 

Low-Dose Ionizing Radiation-Crosslinking Immunoprecipitation (LDIR-CLIP) Identified Irradiation-Sensitive RNAs for RNA-Binding Protein HuR-Mediated Decay

Biology (2023) Dec 15; 12(12):1533 (*Co-corresponding authors)

Taeyun A. Lee, Heonjong Han, Ahsan Polash, Seok Keun Cho, Ji Won Lee, Eun A. Ra, Eunhye Lee, Areum Park, Sujin Kang, Junhee L. Choi, Ji Hyun Kim, Ji Eun Lee, Kyung-Won Min, Seong Wook Yang, Markus Hafner, Insuk Lee, Je-Hyun Yoon, Sungwook Lee, and Boyoun Park 

The nucleolus is the site for inflammatory RNA decay during infection

Nature Communications (2022) Sep 3; 13(1):5203

Ruhi Gulati, Michael Johnston, Maria Rivas, Ashley Cast, Meenasri Kumbaji, Margaret A. Hanlon, Sanghoon Lee, Ping Zhou, Charissa Lake, Emily Schepers, Kyung-Won Min, Je-Hyun Yoon, Rebekah Karns, Lola M. Reid, Dolores Lopez-Terrada, Lubov Timchenko, Sreeja Parameswaran, Matthew T. Weirauch, Sarangarajan Ranganathan, Alexander Bondoc,  James Geller, Gregory Tiao, Soona Shin, and Mikolai Timchenko 

Beta-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma

Hepatology Communications (2022) Aug 24; 00:1-14

Senyo S. Whyte, Rebekah Karns, Kyung-Won Min, Jung-Hyun Cho, Sanghoon Lee, Charissa Lake, Alexander Bondoc, Je-Hyun Yoon, and Soona Shin 

Intergrated analysis using ToppMiR uncovers altered miRNA-mRNA regulatory networks in pediatric hepatocellular carcinoma – A pilot study.

Cancer Reports (2022) Jul 20;e1685

Mi Kyung Park*, Li Zhang*, Kyung-Won Min*, Jung-Hyun Cho, Chih-Chen Yeh, Hyesu Moon, Daniel Hormaechea-Agulla, Hyejin Mun, Seungbeom Ko, Ji Won Lee, Sonali Jathar, Aubrey S. Smith, Yixin Yao, Nguyen Thu Giang, Hong Ha Vu, Victoria C. Yan, Mary C. Bridges, Antonis Kourtidis,  Florian Muller, Jeong Ho Chang, Su Jung Song, Shinichi Nakagawa, Tetsuro Hirose, Je-Hyun Yoon, and Min Sup Song 

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Cell Metabolism (2021) Dec 7; 33, 2380-2397.e2389. (*Co-first authors)

Ji Won Lee, Yoo Lim Chun, Ah Young Kim, Lawson T Lloyd, Seungbeom Ko, Je-Hyun Yoon, and Kyung-Won Min 

Accumulation of mitochondrial RPPH1 RNA is associated with cellular senescence.

International Journal of Molecular Sciences (2021) Jan 14; 22(2):782

Yeo Jin Shin, Eun-Soo Kwon, Seung-Min Lee, Seon-Kyu Kim, Kyung-Won Min, Jae-Young Lim, Bora Lee, Jae Sook Kang, Ju Yeon Kwak, Young Hoon Son, Jeong Yi Choi, Yong Ryul Yang, Seokho Kim, Yeon-Soo Kim, Hak C. Jang, Yousin Suh, Je-Hyun Yoon, Kwang-Pyo Lee, and Ki-Sun Kwon 

A subset of micro RNAs in the Dlk1-Dio3 cluster regulates age-associated muscle atrophy by targeting Atrogin-1.

Journal of Cachexia, Sarcopenia and Muscle (2020) Oct; 11(5):1336-1350

리뷰논문 (2020년 이후)

Shin CH, Kim KM, Ho CW, Lee JW, Jo MJ, Min KW*, Yoon JH* 

Long Noncoding RNAs Regulating Enzymatic Reactions in Cancer 

Experimental & Molecular Medicine (2025) (*co-corresponding authors)

Chul Woong Ho, Ji Won Lee, Chang Hoon Shin*, Kyung-Won Min* 

LncRNA-Encoded Micropeptides: e-x-p-r-e-s-s-i-o-n Validation, Translational Mechanisms, and Roles in Cellular Metabolism 

International Journal of Molecular Sciences (2025) Jun 19; 26(12):5913 (*co-corresponding authors)

Book Chapters (2020년 이후)

Haripriya Gupta, Jayden R Lee, Kane B Hoffman, Kyung-Won Min*, and Je-Hyun Yoon* 

RNA Decay Assay: 5-Ethynyl-Uridine Labeling and Chasing

mRNA Decay: Methods in Molecular Biology. Springer US (2024); pp 139-149 (*co-corresponding authors)

Jung-Hyun Cho, Ji Won Lee, Je-Hyun Yoon, and Kyung-Won Min 

Crosslinking immunoprecipitation and qPCR (CLIP-qPCR) analysis to map interactions of long noncoding RNAs with canonical and non-canonical RNA-binding proteins.

Long noncoding RNAs: Methods in Molecular Biology. Springer US (2021); pp 11-18

Kyung-Won Min, J. Grayson Evans, Erick C. Won, and Je-Hyun Yoon 

Detection of microRNAs released from argonautes

RNA Chaperones: Methods in Molecular Biology. Springer US (2020); pp 151-159

연구논문 (2020년 이전)

Qinyu Sun, Vidisha Tripathi, Je-Hyun Yoon, Deepak K. Singh, Qinyu Hao, Kyung-Won Min, Sylvia Davila, Ricahrd W. Zealy, Xiao Ling Li, Maria Polycarpou-Schwarz, Elin Lehrmann, Yongqing Zhang, Kevin G. Becker, Susan M. Freier, Yuelin Zhu, Sven Diederichs, Supriya G Prasanth, Ashish Lal, Myriam Gorospe and Kannanganattu V. Prasanth 

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs.

Nucleic Acids Research 2018 Nov 2; 46(19):10405-10416

Kyung-Won Min*, Richard W. Zealy*, Sylvia Davila*, Mikhail Fomin, James C. Cummings, Daniel Makowsky, Catherine H. Mcdowell, Haley Thigpen, Markus Hafner, Sang-Ho Kwon, Constantin Georgescu, Jonathan D. Wren, and Je-Hyun Yoon 

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. 

Aging cell 2018 Mar 23;e12753 (*Co-first authors)

Richard W. Zealy, Mikhail Fomin, Sylvia Davila, Daniel Makowski, Haley Thigpen, Catherine H. McDowell, James C. Cummings, Edward S. Lee, Sang-Ho Kwon, Kyung-Won Min*, and Je-Hyun Yoon* 

Long noncoding RNA complementarity and target transcripts abundance.

Biochimica et Biophysica Acta - Gene Regulatory Mechanism 2018 Feb 6; 1861(3):224-234. (*Co-corresponding authors)

Xiaobo Zhang, Pakin Sukamporn, Shiqiang Zhang, Kyung-Won Min, and Seung Joon Baek 

3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells.

Oncology Reports 2017 Jun 1; 38(1):569-574

Kyung-Won Min*, Sylvia Davila*, Richard W Zealy, Lawson T. Lloyd, In Young Lee, Rumi Lee, Kyung Hye Roh, Eui-Ju Choi, Jeong Ho Chang, and Je-Hyun Yoon 

eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation.

Biochimica et Biophysica Acta - Gene Regulatory Mechanism 2017 May 6; 1860(7):761-772. (*co-first authors)

Kyung-Won Min*, Myung Hyun Jo*, Soochul Shin*, Sylvia Davila, Richard W. Zealy, Soo Im Kang, Lawson T. Lloyd, Sungchul Hohng, and Je-Hyun Yoon 

AUF1 facilitates microRNA-mediated gene silencing.

Nucleic Acids Research 2017 Jun 2; 45(10):6064-6073 (*co-first authors)

Kyung-Won Min, Jason Liggett, Gesiel Silva, Wells W Wu, R Wang, Rong-Fong Shen, Thomas E. Eling, and Seung Joon Baek 

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of smad pathway. 

Oncogene 2016 Jan 21; 21;35(3):377-88 4 Kyung-Won Min, Ph.D.

Liggett Liggett, Kyung-Won Min, Smolensky D, and Baek SJ 

A novel COX-independent mechanism of sulindac sulfide facilitates cleavage of epithelial cell adhesion molecule protein.

Experimental Cell Research 2014 Aug 1; 326(1):1-9

Jason L Liggett, Chang K Choi, Robert L Donnell, Kenneth D Kihm, Jong-Sik Kim, Kyung-Won Min, Angelika Anna Noegel, and Seung Joon Baek 

Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 e-x-p-r-e-s-s-i-o-n in colorectal cancer cells.

Biochimica et Biophysica Acta – General Subjects 2014 Jan 1; 1840(1):322-31

Xiaobo Zhang, Seong-Ho Lee, Kyung-Won Min, Michael F McEntee, Jin Jeong, Quingwang Li, and Seung Joon Baek 

The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid.

Cancer Prevention Research 2013 Dec 1; 6(12):1337-47

Xiaobo Zhang, Kyung-Won Min, Jason Liggett, and Seung Joon Baek 

Disruption of the transforming growth factor-β (TGF-β) pathway by tolfenamic acid via the ERK MAP kinase pathway.

Carcinogenesis 2013 Dec 1; 34(12):2900-7

Temjenmongla Imchen, Jorden Manasse, Kyung-Won Min, and Seung Joon Baek 

Characterization of PPAR dual ligand MCC-555 in AOM-induced colorectal tumorigenesis. 

Experimental and Toxicologic pathology 2013 Sep 1; 65(6):919-24

Hataichanok Pandith, Xiaobo Zhang, Jason Liggett, Kyung-Won Min, Wandee Gritsanapan, and Seung Joon Baek 

Hemostatic and Wound Healing Properties of Chromolaena odorata Leaf Extract.

ISRN Dermatology 2013 Aug 1; 2013:168269

Kyung-Won Min, Min Ok Song, Sang-Ryong Park, Young-Seok Oh, and Chang-Ho Lee Nordihydroguaiaretic acid suppresses the lipopolysaccharide-induced activation of macrophage through the down-regulation of TAK1.

Animal cells and systems 2013; 1:15-22

Seong-Ho Lee, Kyung-Won Min, Xiaobo Zhang, and Seung Joon Baek 

3,3'-Diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.

The Journal of nutritional biochemistry 2013 Apr 1; 24(4):664-71

Xiaobo Zhang, Kyung-Won Min, Jay Wimalasena, and Seung Joon Baek 

Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate.

Journal of Cancer Research and Clinical Oncology 2012 Dec 1; 138(12):2051-60

Kyung-Won Min, Xiaobo Zhang, Temjenmongla Imchen, and Seung Joon Baek 

A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4.

Toxicology and Applied Pharmacology 2012 Sep 1; 263(2):225-32

Thararat Nualsanit, Pleumchitt Rohanapanthu, Wandee Gritsanapan, Thiwanporn Kwankitpraniti, Kyung-Won Min, and Seung Joon Baek 

Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kB activity. 

Inflamation & Allergy – Drug Targets 2011 Dec 1; 10(6):455-463

리뷰논문 (2020년 이전)

Richard W. Zealy, Samuel P. Wrenn, Sylvia Davila, Kyung-Won Min*, and Je-Hyun Yoon* 

microRNA-Binding Proteins: Specificity and Function 

Wiley Interdisciplinary Reviews – RNA 2017 Sep 1; 8(5):e1414 (*Co-corresponding authors)

Kyung-Won Min, Seong-Ho Lee, and Seung Joon Baek 

Moonlighting proteins in cancer.

Cancer letters 2016 Jan 1; 370(1):108-16